Methylfolate – Direct-Compression Grade

L-methylfolate is the biologically active form of folate that does not require enzymatic conversion. Offered here as liposomal, phospholipid-complex, microencapsulated, micronized and application-specific grades to improve dispersion, stability and uptake.

Direct-compression grade engineered for flow and compressibility, suitable for tablet manufacture without wet granulation.

GUTINS Methylfolate — direct-compression grade is offered for manufacturers, formulators and brands. Specification: application-grade specification; form / technology: direct-compression grade; diet suitability: Verify carrier.

Product Specifications

Key Benefits

• Active folate form usable regardless of MTHFR status
• Contributes to maternal tissue growth in pregnancy
• Supports normal homocysteine metabolism
• Supports blood formation
• Reduces tiredness and fatigue

Uses & Applications

Typical applications: Tablets, powders, beverages, gummies.

• Prenatal vitamins
• Activated B-complex
• Liposomal folate shots
• Women's multivitamins
• Heart-health blends
• Gummies

How to Use / Dosage

• Typical daily intake: 400-1000 µg DFE/day
• Typical use level: 0.01-0.5% as active in tablets/capsules; often used as 1-10% premixes
• Formulation tip: Blend with standard lubricants (e.g. 0.5–1% magnesium stearate) and compress directly.
• Weigh accurately and pre-blend small quantities with a carrier (e.g. maltodextrin, MCC or rice flour) for uniform distribution.
• Final dosage should be based on the lot-specific Certificate of Analysis, the target serving size and the rules of your destination market.

Solubility & Formulation

Sparingly soluble in water; insoluble in ethanol and oils

Storage & Handling

Store sealed under nitrogen at 2-8 °C or below 25 °C, protected from light, oxygen and moisture; liposomal liquids refrigerated, not frozen.. Keep container tightly closed; use clean, dry utensils. Shelf life is typically 24 months in unopened original packaging (see CoA).

Regulatory Note

Calcium L-methylfolate is an authorised folate source in EU (Directive 2002/46/EC as amended) and a US dietary ingredient. Verify in destination market.

Diet suitability: Verify carrier. This product is supplied as a raw ingredient for further manufacturing and is not a finished consumer product. The buyer is responsible for ensuring the ingredient, its use level and all label claims comply with the regulations of the destination market (e.g. FDA, EFSA, FSSAI, Health Canada, TGA).

Caution & Disclaimer

• Synthetic folate UL of 1 mg/day commonly applied – follow local rules
• May mask B12 deficiency – combine with B12
• Interacts with methotrexate and some anticonvulsants
• Light-, heat- and oxygen-sensitive
• Liposomal/phospholipid grades contain soy or sunflower lecithin – declare source and allergen status

For manufacturing, formulation and professional use only. Not for direct consumption in concentrated form. Keep out of reach of children. Avoid inhalation of dust and contact with eyes; use suitable PPE when handling. Consult a qualified healthcare professional before use if pregnant, nursing, taking medication or managing a medical condition. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Bulk & Wholesale Orders

Need more than 5 Kg, a custom specification, private label support or documentation (CoA, TDS, SDS, allergen and GMO statements)? Contact the GUTINS team for bulk pricing and lead times.