Berberine – Delayed-Release Matrix Powder

Berberine is a bright yellow isoquinoline alkaloid found in barberry, goldenseal and Phellodendron, long used in Ayurvedic and Chinese traditions. Offered here as liposomal, phospholipid-complex, microencapsulated, micronized and application-specific grades to improve dispersion, stability and uptake.

Delayed-release matrix powder engineered to protect the active through the stomach and support release further along the gut.

GUTINS Berberine — delayed-release matrix powder is offered for manufacturers, formulators and brands. Specification: active assay + encapsulation efficiency; form / technology: delayed-release matrix powder; diet suitability: Verify carrier.

Product Specifications

Key Benefits

• Supports healthy glucose metabolism
• Supports healthy lipid levels
• Supports gut microbiome balance
• Traditionally used in Ayurveda and TCM
• Metabolic wellness positioning

Uses & Applications

Typical applications: Premixes, gummies, sachets, tablets, beverages.

• Metabolic support capsules
• Liposomal and phytosome berberine
• Weight management blends
• Cardio-metabolic formulas
• Gut health products

How to Use / Dosage

• Typical daily intake: 500-1500 mg/day in divided doses
• Typical use level: 30-90% in capsule/tablet fills; 5-20% in liposomal powders
• Formulation tip: Avoid milling or high-shear processing that could compromise the release matrix.
• Weigh accurately and pre-blend small quantities with a carrier (e.g. maltodextrin, MCC or rice flour) for uniform distribution.
• Final dosage should be based on the lot-specific Certificate of Analysis, the target serving size and the rules of your destination market.

Solubility & Formulation

Matrix limits dissolution in acidic media; disperses at intestinal pH. Parent active: slightly soluble in cold water, more soluble in hot water; slightly soluble in ethanol; insoluble in oils

Storage & Handling

Store sealed at 15-25 °C, protected from light, heat and moisture; liposomal liquids refrigerated at 2-8 °C and not frozen.. Keep container tightly closed; use clean, dry utensils. Shelf life is typically 24 months in unopened original packaging (see CoA).

Regulatory Note

Berberine is a US dietary ingredient; several EU member states restrict it (some treat it as medicinal or set dose limits). Verify in destination market.

Diet suitability: Verify carrier. This product is supplied as a raw ingredient for further manufacturing and is not a finished consumer product. The buyer is responsible for ensuring the ingredient, its use level and all label claims comply with the regulations of the destination market (e.g. FDA, EFSA, FSSAI, Health Canada, TGA).

Caution & Disclaimer

• Not for pregnancy, breastfeeding or newborns
• Interacts with CYP3A4/2D6 substrates, metformin, cyclosporine
• GI upset and constipation common
• Bitter taste; bright yellow staining
• Liposomal/phospholipid grades contain soy or sunflower lecithin – declare source and allergen status

For manufacturing, formulation and professional use only. Not for direct consumption in concentrated form. Keep out of reach of children. Avoid inhalation of dust and contact with eyes; use suitable PPE when handling. Consult a qualified healthcare professional before use if pregnant, nursing, taking medication or managing a medical condition. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Bulk & Wholesale Orders

Need more than 5 Kg, a custom specification, private label support or documentation (CoA, TDS, SDS, allergen and GMO statements)? Contact the GUTINS team for bulk pricing and lead times.